Infusion of donated antibodies to modulate the immune system in autoimmune conditions.
Intravenous immunoglobulin (IVIG) is a blood product containing pooled antibodies from thousands of donors. It modulates the immune system and is used for various autoimmune and inflammatory conditions.
Key Takeaways
- Modulates immune system
- Infusion of donor antibodies
- Used for autoimmune conditions
- Generally well-tolerated
- May need repeated courses
When It's Used
- Myasthenia gravis
- MOGAD
- Autoimmune optic neuritis
- NMO (adjunctive)
- Thyroid eye disease (in some cases)
- Various inflammatory conditions
How It Works
- Contains many different antibodies
- Blocks harmful antibodies
- Modulates immune response
- Exact mechanism complex and multifaceted
What to Expect
Before Treatment
- Blood tests
- Hydration recommended
- Premedication (Tylenol, Benadryl) common
During Infusion
- IV line placed
- Slow infusion over 4-6 hours
- Usually 2-5 consecutive days
- Monitored for reactions
After Treatment
- Effects may take days to weeks
- May feel tired
- Watch for delayed reactions
Side Effects
Common
- Headache
- Fever, chills
- Fatigue
- Muscle aches
- Nausea
Less Common
- Allergic reactions
- Blood clots
- Kidney problems
- Aseptic meningitis
Reducing Side Effects
- Slow infusion rate
- Premedication
- Adequate hydration
Frequency
- Acute treatment: one course
- Chronic use: every 3-4 weeks
- Depends on condition and response
Compared to Plasma Exchange
- Less invasive (regular IV vs catheter)
- Longer to show effect
- Fewer immediate side effects
- May be used together
Medical Disclaimer: This information is for educational purposes only and does not replace professional medical advice.
Medically Reviewed Content
This article meets our editorial standards
- Written by:
- Hashemi Eye Care Medical Team
- Medically reviewed by:
- Board-Certified Neuro-Ophthalmologist (MD, Neuro-Ophthalmology)
- Last reviewed:
- January 30, 2025